Dupixent and Xolair and COVID-19 Vaccines

Thomas Higgins • January 3, 2022

Dupilumab (Dupixent) and omalizumab (Xolair) are biologics/monoclonal antibodies used to treat nasal polyps and asthma. So, can you take the COVID-19 vaccine while on these medications?
 
 THE TWO FDA-APPROVED VACCINES ARE NOT LIVE VACCINES
 
The two COVID-19 vaccinations currently available (Pfizer-BioNTech and Moderna) are both non-live, mRNA vaccines. The package insert for dupilumab states that live vaccines should be avoided because it has not been studied with live vaccines. Thus, from this standpoint, both of the medicines can be given.
 
 ANTIBODY RESPONSES PRODUCED WITH OTHER VACCINES IN PATIENTS ON BIOLOGICS
 
Dupilumab has been studied with other non-live vaccines and the vaccines worked. In a study of atopic dermatitis adults on dupilumab, both the meningococcal polysaccharide and tetanus vaccines showed similar antibody responses in both placebo-treated and dupilumab-treated subjects.
 
NEITHER MEDICINE HAS IMMUNOSUPPRESSIVE EFFECTS
 
Dupilumab and omalizumab "modulate" or change the behavior of the immune system, but neither medicine has been shown to reduce the immune system in studies.
 
JOINT STATEMENT FROM EXPERTS 
 
According to a Joint Statement by the American Academy of Otolaryngology–Head and Neck Surgery (AAO–HNS) and the American Academy of Otolaryngic Allergy (AAOA), dupilumab (Dupixent) and omalizumab (Xolair) should not be given on the same day but otherwise can be administered on the normal schedule.
 
 CONCLUSION
​
Experts are currently recommending that patients continue dupilumab (Dupixent) and omalizumab (Xolair) when getting the COVID-19 vaccine as long as both the biologic and vaccine are not administered on the same day. Neither medication has been found to lower the immune system and the current vaccines are non-live. Always consult your treating physician for individual medical advice. 
 
 

Cheers,
Thomas S. Higgins, MD, MSPH
  Father. Husband. Sinus Nerd.
 
Source: https://www.entnet.org/content/allergic-reactions-related-covid-19-vaccinations-allergic-patients

A man stopping nosebleed.

How Can I Stop a Nosebleed Quickly?

March 25, 2025
A nosebleed, or epistaxis, refers to blood loss from the delicate tissue lining the nose. Although both nostrils may bleed, typically only one is affected. Nosebleeds are very common, affecting about 60 percent of people at least once in their lifetime. While bleeding from your nose can be alarming or embarrassing, it doesn’t always signal a serious problem. However, nosebleeds that start deeper in the nose or sinuses are more difficult to stop.
A woman with sinus infection.

What Happens if You Let a Sinus Infection Go Untreated?

February 21, 2025
Are you wondering what to do about your sinus infection? Should you have it treated or try to let it clear up on its own? Knowing what can cause these infections and when to seek care is important. Leaving a sinus infection or sinusitis alone may not be the best — or safest — option for you. These infections can lead to other problems in some cases if they’re not treated. We’ll explore what might happen if you delay or even skip treatment for sinusitis.
A diagram of a person 's nose and throat showing nasal polyps

What Are Nasal Polyps?

August 14, 2024
Nasal polyps are soft, noncancerous growths that develop on the lining of the nasal passages or sinuses. They can vary in size and may occur individually or in clusters. While they are usually painless, they can lead to various symptoms and complications. The exact cause of nasal polyps is not fully understood, but they are associated with chronic inflammation in the nasal passages. S
A woman is sitting on a couch holding her nose because she has a sinus headache.

How Will My Surgeon Fix My Chronic Infected Sinuses?

June 7, 2024
Wondering how surgeons tackle chronic infected sinuses? From endoscopic sinus surgery to balloon sinuplasty, they have a range of techniques to alleviate symptoms and improve sinus health. Curious about the process? Let's delve into how these skilled professionals work their magic to bring relief and better breathing!
A woman suffering from a headache is sitting on a couch with her hand on her forehead.

How to Get Rid of a Headache

May 10, 2024
Headaches are a common ailment that can disrupt our daily routines and cause discomfort. Whether it's a tension headache from stress or a migraine triggering intense pain, finding relief is essential. Read on to learn more about headaches and some effective strategies to help you get rid of it.
A young woman suffering from Sinus Infection

Is a Sinusitis Infection Contagious?

By Thomas Higgins • March 18, 2024
Sinus infections (sinusitis) are common and may occur as a primary infection or due to an underlying condition. When a “sinus infection affects someone,” the common question coming from their friends and family is: "Is sinusitis contagious?” It depends on how your infection started.
A woman with red hair is blowing her nose while holding a thermometer and pills.

Is It Better to Take an Oral Decongestant or a Spray for Sinusitis?

By Thomas Higgins • February 10, 2024
When trying to find relief for nasal congestion related to sinusitis, two main types of decongestants are available: oral and nasal spray. But which one is better for you?
A woman with nasal congestion spraying decongestant medication

What Causes Nasal Congestion?

By Thomas Higgins • January 28, 2024
Nasal congestion is a common complaint among people of all ages and can significantly impact quality of life. The symptom can stem from a several causes, including anatomic and inflammatory issues of different areas of the nose. Here, I will discuss more about nasal congestion and how it's treated.

How to Get Rid of a Sinus Headache: Insights from a Sinus Doctor

By Thomas Higgins • December 24, 2023
Learn about sinus headaches from a sinus doctor (rhinologist). Dr. Thomas Higgins sheds light on the common confusion between sinus headaches and sinusitis and how he guides patients through the often-misunderstood journey of pinpointing the true source of their pain and navigating towards effective relief.
Senior man suffering from cold or allergy blows nose snot into a napkin at home

When to See a Rhinologist | A Sinus ENT Specialist

By Thomas Higgins • December 22, 2023
Are you struggling with sinus issues and think you would benefit from seeing a sinus specialist or rhinologist in Louisville, KY? Below is a detailed guide on if a rhinologist is right for you.
More Posts